TBX2 and hepatocellular carcinoma: The same group also profiled prediagnostic plasma DNA methylation and identified hypermethylated TBX2, highly associated with increased HCC risk (OR = 3.2, 95% confidence interval: 1.8–6.0), adjusting for age, HBV surface antigen (HBsAg) status, and anti-HCV status [46].