A large Taiwanese prospective cohort study with 16 years of follow-up, in which 237 HCC cases developed, reported that the overall predictive accuracy of hypermethylated genes (CDKN2A, RASSF1A, STEAP4, TBX2, VIM, and ZNF154) in HCC tumors compared to adjacent tissues was 89% with 84% sensitivity and 94% specificity [25]. This evidence concerns the gene ZNF154 and hepatocellular carcinoma.