CD8A and hepatocellular carcinoma: Figure 1C shows the principal component analysis (PCA) based on the normalized β values of each CpG site. The median proportions of CD8 T cells, CD4 T cells, natural killer lymphocyte cells, and B-cells in HCC patients were numerically higher than those in cirrhosis patients, but the p-values based on the Wilcox rank sum test were >0.05 (Figure 1D).