In vitro overexpression of HOXC8 in breast CSCs reduced stemness by inducing differentiation into epithelial cells, as seen by flow cytometry analysis of CD44/CD24 fractions and reduced expression of aldehyde dehydrogenase (ALDH1), where ALDH1 is a marker of stem-cell-like characteristics and associated with poor survival in breast cancer patients [81]. The gene discussed is ALDH1A1; the disease is breast cancer.