XPO1 is upregulated downstream of RB1/p53 inactivation and was shown to play a key role in T-SCLC, potentially via the upregulation of SOX2 [56], suggesting that induction of XPO1 may also contribute to formation of this high-plasticity intermediate state by driving SOX2 expression. Here, XPO1 is linked to small cell lung carcinoma.