In SCLC cell lines, loss of RB1 results in E2F7 upregulation and epigenetic silencing of YAP [90], which is mediated by the RCOR-HDAC1/2-KDM1A co-repressor (CoREST) complex, although the requirement of KDM1A may vary between different cell lines [90,91]. Here, YAP1 is linked to small cell lung carcinoma.