Importantly, silencing of YAP/TAZ is required for proliferation and metastasis of SCLC and other NE cancers in vitro and in vivo [49,90,91,92,93,94,95], starkly contrasting the oncogenic role of YAP/TAZ in most other solid cancers, including NSCLC [84,85]. This evidence concerns the gene YAP1 and non-small cell lung carcinoma.