Importantly, however, differential methylation patterns explained many of the genes differentially expressed between T-LUAD and T-SCLC tumors, and motifs for key SCLC transcription factors, such as ASCL1 and NEUROD1, became hypomethylated as tumors transitioned to T-SCLC [55]. The gene discussed is NEUROD1; the disease is small cell lung carcinoma.