Resistant NE-like sub-clones derived from four different NSCLC lines exhibited downregulation of RB1 and EGFR protein; upregulation of classic NE markers, such as CHGA; and increased sensitivity to chemotherapeutic agents used to treated SCLC, suggesting transition to an SCLC-like state [48]. The gene discussed is RB1; the disease is non-small cell lung carcinoma.