Further analysis of transcriptional differences between T-LUAD and T-SCLC revealed increased expression of cell cycle, DNA repair, chromatin remodeling, WNT signaling and PR2C target genes in T-SCLC, along with decreased expression of negative regulators of PI3K/AKT signaling, immune-related genes and RTK signaling [55]. Here, PIK3CA is linked to small cell lung carcinoma.