BDNF and cancer: By comparing the effects of growth factor treatment on the control and SORL1 knockdown cell lines, we identified that SORL1 was involved in the cancer cell growth stimulated by CXCL12, BDNF, FGF1, and EGF1 in OVCAR8 cells (Figure 3A) and by BDNF, FGF1, and EGF1 in KRCH31 cells (Figure 3B).