Based on our data that SORL1 was upregulated in recurrent tumors, and that it promoted carboplatin resistance and the expression levels of epidermal growth factor receptor (EGFR) and fibroblast growth factor receptor 4 (FGFR4), we further hypothesize that SORL1 regulates the endosomal trafficking and stability of EGFR and FGFR4 to promote the platinum resistance of recurrent ovarian cancer. Here, FGFR4 is linked to ovarian carcinoma.