IFNG and neoplasm: However, K562-A2 cells triggered similar amounts of IFN-γ in the IMPs analyzed, as seen in comparison to co-cultures with PRAME VLD-loaded T2 or Mel624.38 cells, indicating that this tumor cell line is generally recognized by MDG1011 and target cell-intrinsic characteristics other than peptide-HLA complex expression may be responsible for suboptimal killing of K562-A2 by several IMPs.