AKT1 and liver cancer: The overexpression of regucalcin blocked the G1 and G2/M phases of the cell cycle and the proliferation of human liver cancer cells by inhibiting several signaling pathways, including calcium, Ras, Akt, MAP kinase, SAPK/JNK, NF-κB p65, β-catenin, c-fos, and c-myc signaling, while increasing p21, p53, and Rb [34].