GPC3 has been linked to HCC tumorigenesis through multiple mechanisms, including the recruitment of TAMs, enhancing glucose metabolism, EMT, apoptosis resistance via the Bax/Bcl-2 pathway, and cellular signaling, like the Wnt-β-catenin pathway [74,75] (Figure 1(6d)). The gene discussed is GPC3; the disease is hepatocellular carcinoma.