In mouse mammary tumors treated with E7386, an inhibitor of the interaction between CBP and β-catenin, there was demonstrated downregulation in genes related to hypoxia and increased infiltration of CD8+ T cells into tumor tissues; similar in vivo antitumor activity was seen when E7386 was combined with an anti-PD-1 mAb [143]. The gene discussed is PDCD1; the disease is neoplasm.