GPC3 and hepatocellular carcinoma: In designing an effective GPC3-targeted ADC, Fu et al. screened over 9000 compounds against HCC cell lines and identified DNA-alkylating agents, duocarmycin SA and pyrrolobenzodiazepine dimer, as the most potent payloads to construct two GPC3-specific ADCs, hYP7-DC and hYP7-PC, respectively.