Growth differentiation factor (GDF15) in particular is a member of the TGF superfamily that exerts its immunosuppressive actions in HCC through Tregs, where it binds to the CD48 receptor inhibiting the ERK-Activator protein 1 pathway, causing downstream FOXP3 accumulation and HCC development [40,41]. This evidence concerns the gene GDF15 and hepatocellular carcinoma.