Clinical informaticists have attempted to develop nomograms for tumor response in patients treated with ICI plus targeted therapy; those to date have identified clinical characteristics, such as tumor size less than 5 cm, higher AFP response (defined as a decline of ≥20% in AFP levels within the initial eight weeks of treatment), fewer extrahepatic metastasis, and lower leukocyte count, as being associated with a higher ORR and PFS [174,175,176]. This evidence concerns the gene AFP and neoplasm.