A study by Zhang et al. revealed that 20% of CNL cases have ten-eleven translocation-2 (TET2) mutations, while also showing that only 5.7% of patients had DNMT3A mutations [57], and another study by Meggendorfer et al. [48] revealed that 30% of cases carry TET2 mutations. The gene discussed is TET2; the disease is chronic neutrophilic leukemia.