CD274 and neoplasm: Furthermore, administering an engineered strain of Enterococcus hirae in which its prophage expresses a major histocompatibility complex (MHC) epitope enhanced the response to immunotherapy, and immune checkpoint inhibitors such as anti-programmed cell death 1 ligand 1 (anti-PD-1) antibody treatment, these therapies can reactivate T cells, allowing them to attack cancer cells more effectively due to cross-reactivity between tumor antigens and the bacteriophage [190].