TLR4 and colorectal carcinoma: Since LPS is an important product of the gut Gram-negative microbiota, associated with intestinal inflammation and CRC progression through the TLR4- NF-kB pathway [198], the delivery of these LPS-trap nanoparticles to the orthotopic tumors has led to the blockage of LPS-TLR4 interactions in the tumor microenvironment.