KLK3 and Anxiety: The timing of ADT initiation should be personalized based on factors such as PSA velocity, patient anxiety, and potential side effects. In particular, patients with a shorter PSADT or rapid PSA velocity, coupled with a long-life expectancy, may benefit from early initiation of ADT. Addition of enzalutamide could be useful in certain circumstances. On the other hand, patients with longer PSADTs, especially those who are older, may be better suited for an observation approach, monitoring their condition without immediate ADT intervention.