GSPT1 and leukemia: Previous findings showed that depletion of GSPT1 by the molecular glue degrader CC-90009, a cereblon E3 ligase modulating drug that coopts CRL4CRBN to selectively target GSPT1 ubiquitination and proteasomal degradation (Figure 4A), rapidly induces AML apoptosis and reduces leukemia engraftment [17].