Danielsen et al. detected hypermethylation of promoter of RASSF1A in 60% of MPNST samples, which is also correlated with poor prognosis of NF1-associated MPNST, indicating RASSF1A might be a prognostic predictor in a subset of MPNSTs [78]. This evidence concerns the gene RASSF1 and malignant peripheral nerve sheath tumor.