A detailed stratification analysis of RCC patients and controls based on epidemiological and clinical characteristics revealed that MDM2 rs2279744 genotypes significantly influenced RCC susceptibility among smokers (Figure 2A), alcohol consumers (Figure 2B), individuals with hypertension (Figure 2C), diabetes (Figure 2D), and those with a family history of cancer (Figure 2E). This evidence concerns the gene MDM2 and renal cell carcinoma.