Noticeably, individuals carrying the heterozygous GT or homozygous GG genotypes of MDM2 rs2279744 exhibited an elevated risk of RCC, with ORs of 1.35 (95% CI = 0.79–2.30, p = 0.3346) and 2.13 (95% CI = 1.22–3.71, p = 0.0098), respectively. This evidence concerns the gene MDM2 and renal cell carcinoma.