However, the percentage of WNT-positive cells in the lamina propria was seen to increase from the early-stage to late-stage Dukes A to Dukes D. This could be a manifestation of epithelial–mesenchymal transition (EMT) initiation, which happens in more advanced stages of CRC, Dukes C and D. This represents excellent pilot data that could be considered in future studies focused on the evaluation of WNT4’s role in CRC. The gene discussed is WNT4; the disease is colorectal carcinoma.