In summary, UBR5 interacts with key proteins such as MOAP-1, MOIP-1, β-catenin, TXNIP, MYC, CDC73, CAPZA1, TIP60, GKN1, and ECRG4, NF-kB, highlighting its pivotal roles in promoting metastasis, therapeutic resistance, and cancer cell survival. Here, MYC is linked to cancer.