INS and metabolic disease: Previous scientific reports emphasize the benefits of the Mediterranean diet in patients with metabolic diseases, made possible by its richness in antioxidants, monounsaturated fatty acids, fiber, well-digested animal protein, and polyphenols—the interplay of which reduces intrahepatic triglyceride accumulation, influences the expression of genes related to adipogenesis and adipocyte proliferation, sensitizes peripheral tissues to insulin (while regulating its secretion), and enhances the inflammatory response associated with adipose tissue activity [22].