AIM2 and neoplasm: So far, tumor-derived or chemotherapy-induced ICD with an ensuing release of alarmins is able to activate the NLRP3 inflammasome due to the alteration of the mitochondrial homeostasis [10] or the AIM2 inflammasome after the recognition of double-stranded DNA (dsDNA) released by dying cells [19,20,21,22,23,24].