The most frequent concomitant mutations in RAS-mutated AML are FLT3, NPM1, DNMT3A, ASXL1, IDH2, and RUNX1; astonishingly, their incidence has not been shown to be significantly different from that in AML with wild-type RAS [2,95]. The gene discussed is NPM1; the disease is acute myeloid leukemia.