The most frequent concomitant mutations in RAS-mutated AML are FLT3, NPM1, DNMT3A, ASXL1, IDH2, and RUNX1; astonishingly, their incidence has not been shown to be significantly different from that in AML with wild-type RAS [2,95]. This evidence concerns the gene DNMT3A and acute myeloid leukemia.