Human immunodeficiency virus type I enhancer binding protein 2 (HIVEP2) encodes atranscription factor with zinc finger domains that regulates many neurodevelopmental pathways and it has been identified in many neurodevelopmental disorders, intellectual disability, behavioral symptoms, hypotonia, autism spectrum disorders, and microcephaly [34,35,36,37]. This evidence concerns the gene HIVEP2 and microcephaly.