The deCODE database analysis identified PLXND1 and TNFSF14 as genes linked to a reduced risk of PRAD (Figure 3, Table S5), while NEGR1, REG4, ECM1, GNMT, POR, MTHFD1, and GSTZ1 were associated with increased PRAD risk. The gene discussed is MTHFD1; the disease is prostate adenocarcinoma.