MARCO, LAYN, and IL10RB were linked to reduced PRAD risk, while C1QA, TXNDC15, IGFBP3, TNFRSF10C, TRIM5, JAM3, RNF43, PPP1R14A, SPINT2, and LGALS4 were associated with increased risk (Figure 2, Table S2). This evidence concerns the gene RNF43 and prostate adenocarcinoma.