Then, using cis-pQTL data in UKB-PPP and deCODE, the MR analysis identified CRHBP, GFRAL, NTRK3, SERPINA1, SERPINA3, and SLAMF7 as being associated with increased PRAD risk, whereas COL2A1, MSMB, POSTN, and RNASE3 were associated with reduced PRAD risk (Figure 4, Table S8). Here, COL2A1 is linked to prostate adenocarcinoma.