LEPR and obesity due to melanocortin 4 receptor deficiency: Mice from both obesity models (alimentary and that caused by leptin receptor deficiency) showed significantly higher body weight compared to the C57Bl6 mice fed an SD (Table 1): the mean body weights of HFD-fed C57Bl6 and SD-fed db/db mice were, respectively, 22% and 95% higher than mean body weight of SD-fed C57Bl6 mice.