KRAS and Familial prostate cancer: PC-3 cells in the prostate cancer dataset GSE179990 [37] showed greater overall enrichment in samples expressing the shorter isoform (318 bp long) of NF-YA, than its longer isoform (347 bp long) (Figure 3A), with the top signature being ‘KRAS.600_UP.V1_UP’ (NES = 2.049, p-value < 0.001) (Figure 3B).