In renal cancer, tumorous samples from RCC tissue in the dataset GSE167573 [38] enriched a larger number of signatures than controls (Figure 3C), with the highest being ‘HOXA9_DN.V1_UP’ (NES = 3.138, p-value < 0.001) (Figure 3D), while samples affected by IgA nephropathy in GSE141295 [39] also showed more enrichment than unaffected controls (Figure 3C), with the top signature being ‘TBK1.DF_DN’ (NES = 2.524, p-value < 0.001) (Figure 3E). Here, TBK1 is linked to IgA glomerulonephritis.