In this study, we conducted an in-depth analysis of TLR7, an immune-related gene in the tumor microenvironment (TME), using extensive bioinformatics methods, and found that this gene was effective in predicting the treatment efficacy and prognosis of patients with LUAD, and had a predictive value for the response to immunotherapeutic and chemotherapeutic agents. Here, TLR7 is linked to neoplasm.