Identified a three-mRNA signature that is associated with the OS of OSCC patients.A three-mRNAs were identified as a prognostic biomarker pattern for OSCC (CLEC3B, C6 and CLCN1).These three-mRNA signature were regarded as risk genes and may serve as tumor suppressor in OSCC, and the downregulation of these mRNAs in OSCC indicated poor prognosis.Did not report the correlation with immune cell in this study. This evidence concerns the gene CLCN1 and neoplasm.