The chemosensitizing effect of DMAMCL was associated with its direct interaction with plasminogen activator inhibitor-1 (PAI-1), which is up-regulated in glioblastoma cells and controls their aggressiveness [65], and the inhibition of Akt activation through the down-regulation of AEBP1 [24]. The gene discussed is SERPINE1; the disease is glioblastoma.