HMOX1 and glioblastoma: Furthermore, a number of STLs led to the overexpression of key Nrf2-dependent anti-oxidant proteins in glioblastoma cells, namely, NADPH oxidase 1 (NOX1), thioredoxin (TrX), heme oxygenase 1 (HO1), and superoxide dismutase 2 (SOD2) by DMAMCL [66] and catalase (CAT), glutathione peroxidases 1 and 4 (GPX1/4), and SOD2 by dihydroartemisinin [78].