AKT1 and glioblastoma: The multidirectional effects of STLs against glioblastoma cells described above were mediated by their blocking effect on a number of key signaling pathways, including NF-κB [18,22,55,58,62,66,67,72], STAT3 [15,56,67,83,85], PI3K/Akt/mTOR [22,24,52,65,72,76,77,85], EGFR [60,77,79], and MAPK [22,68] pathways, which play a critical role in glioblastoma pathogenesis [116].