PKM and glioblastoma: The revealed inhibitory potency of DMAMCL with respect to anaerobic metabolism in U118 cells was found to be mediated by the direct interaction of micheliolide, a major metabolite of DMAMCL, with pyruvate kinase M2 (PKM2), resulting in the increase in pyruvate kinase activity and subsequent suppression of lactate production in glioblastoma cells [21].