Although the precise pathogenesis of HSP is undetermined, pathological and laboratory findings, such as a vascular deposition of the IgA-dominant immune complex, the infiltration of small blood vessels with polymorphonuclear leukocytes, the presence of leukocyteoclasia, increased serum IgA, and proinflammatory cytokines, indicate that HSP is an immune-mediated disease [8,9]. Here, CD79A is linked to hereditary spastic paraplegia.