Analysis with the IPA tool identified 14 enzymes related to tumor invasion (MME, MTHFD1, FLT4, AMFR, FER, PRKCA, ALDOB, AOX1, PSMD1, PRPS1, PRDX2, NDST1, RNASE1, F2) (Figure 8). This evidence concerns the gene MTHFD1 and neoplasm.