- Surgery: Radical cystectomy for localized disease- Chemotherapy: Platinum-based regimens (e.g., FOLFOX, CAPOX) similar to colorectal cancer- Targeted Therapy: Potential use of therapies effective in colorectal cancer (e.g., EGFR inhibitors)- Immunotherapy: Limited efficacy due to low tumor mutation burden and reduced PD-L1 expression- ADCs: Enfortumab vedotin shows limited efficacy in pure adenocarcinoma but works better in mixed histologies. The gene discussed is EGFR; the disease is colorectal cancer.