- Cellular Components: Immune cells, fibroblasts, cytokines (IL-6, TNF-α, TGF-β), and extracellular matrix.- Signaling Interactions: Cytokines and hypoxic conditions drive subtype differentiation.- Supportive Niche: Cancer-associated fibroblasts (CAFs) and ECM remodeling facilitate tumor progression. The gene discussed is TNF; the disease is cancer.