TGFB1 and cancer: - Cellular Components: Immune cells, fibroblasts, cytokines (IL-6, TNF-α, TGF-β), and extracellular matrix.- Signaling Interactions: Cytokines and hypoxic conditions drive subtype differentiation.- Supportive Niche: Cancer-associated fibroblasts (CAFs) and ECM remodeling facilitate tumor progression.