- Non-Urachal: KRAS, MYC, FLT3, and TERT mutations- UrCA: SMAD4, GNAS mutations; lower frequency of TERT and RB1 than that of non-urachal- Shared mutations with colorectal cancer (e.g., TP53, KRAS, and APC). The gene discussed is SMAD4; the disease is colorectal cancer.