GRN and Alzheimer disease: A 2022 detailed study concerning the involvement of microglial cleavage in AD development showed that genes involved in lysosomal function and autophagy, such as granulin (GRN) and transmembrane protein 106B (TMEM106B), significantly influence the ability of microglia to clear Aβ deposits, thus raising the issue of potential identification of new therapeutic targets [49].