CFTR and cystic fibrosis: We previously conducted a screening of a small compound library and identified LSO-24, a hydroxyl-1,2,3-triazole derivative, as a promising candidate that was able to enhance p.Arg334Trp-CFTR function with a suboptimal efficacy and potency in both heterologous systems and in intestinal organoids from a p.Arg334Trp-homozygous CF subject [34].