Compared to the control group (UNx-HS db/m), the UNx-HS db/db mice showed hypertension, accompanied by massive albuminuria, glomerular damage with nodular lesions, and high expression of serum- and glucocorticoid-induced protein kinase 1 (SGK1), a target of MR, and truncated ENaC. This evidence concerns the gene NR3C2 and hypertensive disorder.