Notably, Activating Transcription Factor 3 (ATF3) enhances glioma cell ferroptosis by promoting hydrogen peroxide and iron accumulation [14], whereas Activating Transcription Factor 4 (ATF4) triggers ferroptosis through Solute Carrier Family 7 Member 11 (SCL7A11)/SCX-dependent mechanism [15]. The gene discussed is ATF3; the disease is glioma.