Similar to AD, TBI/CTE, and stroke/VaD, our group demonstrated a preE-associated Pin1 inactivation by cysteine-113 (Cys113) oxidation [36,46], and Ser71 phosphorylation by death associated protein kinase 1 (DAPK1) [44,45,119,120], and concomitant induction and cytoplasmic sequestration of cis P-tau and protein aggregation [49]. The gene discussed is PIN1; the disease is stroke disorder.