Flt-1, KDR (VEGFR-2), and NRP1 spliced variants can exist as transmembrane receptors that signal intracellular receptor tyrosine kinase (RTK) cascades or truncated soluble receptors such as sFlt-1 that scavenges agonists of Flt-1 [203,223,224] leading to the multisystem endothelial dysfunction characteristic of preE [225,226,227]. This evidence concerns the gene FLT1 and endothelial dysfunction.