Even without a significant change in serum lipid levels, absence/deficiency of the protective ApoE as in ApoE knockout mice [239] could produce preE features, including elevated Toll-like receptor 4 (TLR4) and sFlt-1 expression, as well as high systolic blood pressure, proteinuria, thickening and edema of glomerular filtration membrane, and capillary thrombosis [239]. The gene discussed is APOE; the disease is deep vein thrombosis.