A systematic review and individual patient-level meta-analysis suggested that pancreatic stone protein/regenerating protein (PSP/Reg, also regarded as lithostathine or Reg1) was a promising biomarker for diagnosing infections and predicting infection severity and ICU mortality, outperforming C-reactive protein (CRP) or procalcitonin (PCT) [122,123]. Here, REG1A is linked to infection.