Besides being highly expressed in pancreatic tissue, Reg proteins were also found to be inducible in the intestinal tract [43,44], particularly Reg1 and Reg3 subfamily proteins that were induced by IL6/IL22 in inflammatory bowel disease (IBD) for mucosal regeneration through STAT3 activation [45,46,47,48]. The gene discussed is STAT3; the disease is inflammatory bowel disease.