Patients with a compound heterozygous variant (RNF213 p.R4810K variant together with other rare variants) exhibited a more severe form of the disease characterized by younger onset, posterior cerebral artery involvement, and a higher percentage of presentation with infarction, as compared to patients with the heterozygous RNF213 p.R4810K variant alone [27]. This evidence concerns the gene RNF213 and infarction.