Secondly, histopathologic studies revealed similar characteristics between the various associated vasculopathies—the proliferation of the smooth muscle cells is the cause of the arterial occlusion in MMD and is also part of the mechanism of atherosclerosis in coronary heart disease [76,77], for which RNF213 p.R4810K is also an identified risk locus [43]. The gene discussed is RNF213; the disease is coronary artery disorder.