Dyslipidemia is a prominent metabolic disease characterized by abnormal changes in lipids including high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, total cholesterol (TC), triglyceride (TG), apolipoprotein A-I (APOA1), and apolipoprotein B (APOB). This evidence concerns the gene APOA1 and metabolic disease.