PLAU and lung carcinoma: In lung cancer cells and in human gastric adenocarcinoma cells, δ-TT and γ-TT downregulated the expression of metastatic markers, such as matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) and urokinase-type plasminogen activator (uPA), which are deeply involved in the degradation of the extracellular matrix, while increasing the expression and activity of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) [164,186,187].