ERBB2 and breast carcinoma: Our data are consistent with those of Viola and coworkers, which reported that, in HER2/Neu-overexpressing breast cancer cells, δ-TT induces mitochondrial destabilization and impairment of ATP production, associated with alterations in stress/survival signaling pathways (p38 and ERK1/2), and increased ROS production leading to apoptotic cell death [202].