However, it has been suggested that the BRCA1 gene can also reduce the damage to ovarian cancer cells by activating the antioxidant defence system, whereas the BRCA gene deletion disrupts the redox balance by affecting the expression of Nrf2, leading to the excessive production of ROS and, ultimately, to the formation of oxidative stress that damages ovarian cancer cells [132]. This evidence concerns the gene NFE2L2 and ovarian carcinoma.