However, it has been suggested that the BRCA1 gene can also reduce the damage to ovarian cancer cells by activating the antioxidant defence system, whereas the BRCA gene deletion disrupts the redox balance by affecting the expression of Nrf2, leading to the excessive production of ROS and, ultimately, to the formation of oxidative stress that damages ovarian cancer cells [132]. The gene discussed is BRCA1; the disease is ovarian cancer.