It was found that under oxidative stress, the Keap1-Nrf2-ARE pathway could not only reduce the damage of oxidative stress on ovarian cancer cells by inducing the production of antioxidant enzymes, such as glutathione peroxidase (GPX), but also help tumour cells to resist the attack of chemotherapeutic drugs and enhance the chemoresistance of ovarian cancer cells by activating the expression of downstream detoxification genes [66]. Here, NFE2L2 is linked to neoplasm.