PRDX5 and acute kidney injury: For example, protein levels of Prdx5 were decreased in autosomal dominant polycystic kidney disease (ADPKD) [28], I/R-induced acute kidney injury [21], UUO-induced renal fibrosis [22,23], etc. When ectopic overexpression of Prdx5 was performed, this pathophysiological phenomenon was alleviated [21,22,23,28].