SIRT1 and osteoarthritis: In a complementary study, Du et al. (2021) explored FA’s effects on IL-1β-induced chondrocyte degeneration in osteoarthritis, revealing that this compound activates the Sirtuin 1/Activated Protein Kinase/Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha signaling pathway to mitigate chondrocyte degeneration by reducing inflammatory mediators and oxidative stress, positioning FA as a promising therapeutic agent for osteoarthritis [143,144].