Ma et al. showed that bilobalide alleviates osteoarthritis in rats by inhibiting iNOS and COX-2 protein expression through the AMPK/SIRT1/mTOR pathway [85], while Shen et al. reported that paeonol improves hyperlipidemia and autophagy by targeting the Nrf2 and AMPK/mTOR pathways [86]. This evidence concerns the gene MTOR and osteoarthritis.