The changes in ROS, MDA, and autophagical flux in Figure 1b–i, reduction in phosphorylate-mTOR, and increase in phosphorylate-AMPK, phosphorylate-ULK1 and LC3B at protein level after giving GENI in Extended Data Figure S3a–f clarified that GENI shows neuroprotection and anti-AD effects through anti-oxidative stress and autophagy induction via AMPK/mTOR/ULK1/LC3B signaling pathway. Here, MAP1LC3B is linked to Alzheimer disease.