Hypertension produced an increase in the content of superoxide anions in aortic tissue (Figure 7A,B; p < 0.001) along with increased mRNA levels of the prooxidant enzymes Nox1 (Figure 7C; p < 0.01) and Nox4 (Figure 7D; p < 0.05). The gene discussed is NOX4; the disease is hypertensive disorder.