Among them, compared to the H2O2 group, the low-dose PV group did not exhibit a significant trend in decreasing STAT3 protein expression level (p > 0.05), while the other PV treatment groups significantly reduced the protein expression levels of ESR1, JAK2, MMP2, and STAT3 (p < 0.05). This evidence concerns the gene JAK2 and acquired polycythemia vera.