ESR1 and breast cancer: For instance, pretreatment with kolaviron can significantly reverse the increased expression of ESR1, the elevated levels of MDA, and pro-inflammatory cytokines, as well as the decreased activities of antioxidant enzymes (GSH-Px, CAT, SOD) induced by 7, 12-dimethylbenzanthracene (DMBA) in rats, thereby alleviating the impact of oxidative stress-related breast cancer in rats [59].