BPIFB4 and Huntington disease: Furthermore, in a cellular model of Huntington’s disease (HD), LAV-BPIFB4 infection reduces nucleolar stress and DNA damage through the inhibition of the levels of H3K9me3, which are usually associated with transcriptional repression and heterochromatinization occurring in mature HD neurons, by accelerating histone clearance via the ubiquitin–proteasome pathway [32].