Among the various mechanisms of protection, the immune system plays a primary role in maintaining tissue homeostasis by eliminating cells that escape internal regulatory controls (e.g., cancer cells) or clearing the circulatory stream of factors that may cause tissue damage [60,61,62,63] activity and the pro-release of cytokines inflammatory [64,65,66] KDM6B (JMJD3), which is induced by inflammatory mediators such as IL-4 and TGF-β and regulates inflammatory and immune responses by removing the repressive epigenetic signs, thus triggering cellular senescence [67,68]. Here, KDM6B is linked to cancer.