Through the modulation of the SIRT6/NF-KB and Nrf2/NF-KB signaling pathways to activate SIRT6 and downregulate the expression of ADAMTS-4, MMP-13, COX-2, and iNOS, articular chondrocyte degradation is prevented, and the inflammatory response in osteoarthritis (OA) is mitigated [136]. The gene discussed is MMP13; the disease is osteoarthritis.