AQP11 and type 2 diabetes mellitus: After adjusting for age, sex, baseline serum creatinine, and comorbid diseases, the multivariate logistic regression showed that T2D patients with the AQP11 rs2276415 polymorphism were at a 2.25 times higher risk of developing CKD compared with T2D patients with the wild-type allele (p = 0.006).