SPP1 and chronic kidney disease: Using another model that took into consideration the interactions between SNPs, hypertension, and diabetes, the authors identified a hypothetical high-risk patient profile (male, non-Caucasian, with diabetes and hypertension), where the presence of the five SNPs (SPP1 s1126616, MMP3 rs35068180, BGLAP rs1800247, MGP rs4236, and CYP24A1 rs2248359) increased the risk of CKD by six times [24].