In a multicenter, observational, prospective cohort study of 124 CKD patients in Malaysia, the CYP3A5 rs776746 genetic polymorphism, encoding one of the most common CYP450 proteins among the Asian population, was associated with rapid CKD progression (adjusted OR 4.190, 95% CI 1.268–13.852). This evidence concerns the gene CYP3A5 and chronic kidney disease.