AQP11 and chronic kidney disease: In a prospective cohort study of 620 Chinese CKD patients, the AQP11 rs2276415 variant was significantly associated with an increased risk of CKD progression in a univariate (HR 3.20, 95% CI 2.35–4.36, p < 0.001) and multiple Cox regression model adjusted for the risk factors (HR 1.92, 95% CI 1.31–2.84, p = 0.001) [20].