In the VEGF/angiogenesis pathway, hypoxic tumors secrete VEGF that activates phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) and mitogen-activated protein kinase (MAPK) pathways, leading to leaky and dysfunctional vasculature, contributing to embolism and stroke risk. This evidence concerns the gene AKT1 and stroke disorder.