Similarly, Li et al., who investigated the role of exosomal mediated secretion of lysyl oxidase-like 4 on the ability of hepatocellular carcinoma cell invasion and metastasis, reported that hepatocellular carcinoma-derived exosomes with lysyl oxidase-like 4 caused tumor invasion and metastasis in human umbilical vein endothelial cells (HUVECs) [33]. This evidence concerns the gene LOXL4 and neoplasm.