Other ACSL4 inhibitors, such as thiazolidinediones, including rosiglitazone, pioglitazone, and troglitazone, can reduce ferroptosis and lipid peroxidation induced by RSL3 and GPX4 knockout, similarly reducing oxidative stress and inflammation in CKD to protect the kidneys [201,202,203]. The gene discussed is ACSL4; the disease is chronic kidney disease.